NOVEL DUAL NITRIC OXIDE RELEASING ANTI-REMODELING THERAPY FOR HYPERTENSIVE HEART DISEASE
نویسندگان
چکیده
منابع مشابه
A Novel Index of Remodeling in Hypertensive Heart Disease.
Left ventricular hypertrophy (LVH) is thought to be an adaptive response that allows for normal ejection fraction despite abnormal pressure or volume load, or a combined pressure and volume load. However, this adaptation is associated with substantially increased morbidity and mortality. Echocardiography helped create the dossier on the prevalence and consequences of LVH in hypertension and out...
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Hypertensive heart disease (HHD) occurs in patients that clinically have both diastolic and systolic heart failure and will soon become the most common cause of heart failure. Two key aspects of heart failure secondary to HHD are the relatively highly prevalent LV hypertrophy and cardiac fibrosis, caused by changes in the local and systemic neurohormonal environment. The fibrotic state is marke...
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everal decades ago, the severity of heart failure was gauged ccording to a depression in myocardial contractility, dened as that biochemical property of cardiac muscle that etermines the extent of shortening independent of its nitial length and the load against which it shortens. athematical models were used to derive indices of conractility (1). These theoretical constructs included a conracti...
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Nitric oxide (NO) plays an important role in the maintenance and regulation of the skin and the integrity of its environment. Derangement of NO production is implicated in the etiology of a multitude of dermatologic diseases, indicating future therapeutic directions. In an era of increasing resistance rates to available antibiotics and subpar development of new agents, NO is promising as a pros...
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BACKGROUND Stable plasma nitric oxide (NO) metabolites (NOM), composed predominantly of nitrate and nitrite, are attractive biomarkers of NO bioavailability. NOM levels integrate the influence of NO-synthase-derived NO production/metabolism, dietary intake of inorganic nitrate/nitrite, and clearance of NOM. Furthermore, nitrate and nitrite, the most abundant NOM, can be reduced to NO via the ni...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(11)60609-8